2K Games and Gearbox Software announced that the PC version of Duke Nukem Forever will use Valve's Steamworks as its DRM solution. This means that the game will be intimately tied to your Steam account. More from Gearbox Community manager Chris Faylor (via the company's official forum):
"2K Games and Gearbox Software today officially announced that the PC release of Duke Nukem Forever will incorporate Steamworks.
What does this mean for you?
It means that regardless of where or how you buy Duke Nukem Forever on PC, your purchase will be tied to your Steam account, ensuring that you'll always be able to install a copy of the game even if you lose your disc. "
Later in the thread Faylor confirms that Steamworks will be the only DRM used with the game.
Duke Nukem Forever releases May 3 in the United States and on May 6 internationally.
Source: Blue's News